Comparative Study of the Regioselectivity and Reaction Media for the Synthesis of 1??tert??Butyl??3 (5)??trifluoromethyl??1H??pyrazoles

…, VP Andrade, N Zanatta, HG Bonacorso

Index: Martins, Marcos A. P.; Marzari, Mara R. B.; Frizzo, Clarissa P.; Zanatta, Marcileia; Buriol, Lilian; Andrade, Valquiria P.; Zanatta, Nilo; Bonacorso, Helio G. European Journal of Organic Chemistry, 2012 , # 36 p. 7112 - 7119

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Citation Number: 10

Abstract

Abstract A study is presented for the synthesis of a series of 1-tert-butyl-3 (5)-(trifluoromethyl)- 1H-pyrazoles from the reaction of 4-alkoxy-1, 1, 1-trifluoro-3-alken-2-ones [CF 3 C (O) CH= C (R 1)(OR), where R= Et and R 1= H or R= Me and R 1= Me, Ph, 4-Me-C 6 H 4, 4-MeO-C 6 H 4, 4-FC 6 H 4, 4-Cl-C 6 H 4, 4-Br-C 6 H 4, 4-IC 6 H 4, fur-2-yl, thien-2-yl, or naphth-2-yl] with tert-butylhydrazine hydrochloride. When [BMIM][BF 4](1-butyl-3-methylimidazolium ...