Crystal Structure of the Homo sapiens Kynureninase-3-Hydroxyhippuric Acid Inhibitor Complex: Insights into the Molecular Basis Of Kynureninase Substrate …

S Lima, S Kumar, V Gawandi, C Momany…

Index: Lima, Santiago; Kumar, Sunil; Gawandi, Vijay; Momany, Cory; Phillips, Robert S. Journal of Medicinal Chemistry, 2009 , vol. 52, # 2 p. 389 - 396

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Citation Number: 28

Abstract

Homo sapiens kynureninase is a pyridoxal-5′-phosphate dependent enzyme that catalyzes the hydrolytic cleavage of 3-hydroxykynurenine to yield 3-hydroxyanthranilate and l-alanine as part of the tryptophan catabolic pathway leading to the de novo biosynthesis of NAD+. This pathway results in quinolinate, an excitotoxin that is an NMDA receptor agonist. High levels of quinolinate have been correlated with the etiology of neurodegenerative ...