Journal of Pharmaceutical Sciences 2002-07-01

Theoretical and experimental investigations on the morphology of pharmaceutical crystals.

David S Coombes, C Richard A Catlow, Julian D Gale, Martin J Hardy, Martin R Saunders

Index: J. Pharm. Sci. 91(7) , 1652-8, (2002)

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Abstract

We investigated the morphologies of three polymorphs of 1,3-di(cyclopropylmethyl)-8-aminoxanthine, a compound of pharmaceutical importance. We compared the experimental morphologies with those predicted by theoretical methods. We also predicted the elastic constants of the three polymorphs. These results are used to help assess the stabilities of the three polymorphs and compare the abilities of theoretical methods to reproduce experimental morphologies.Copyright 2002 Wiley-Liss Inc.

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