Organic letters

… synthesis of 1, 3-disubstituted tetrahydroisoquinolines: a stereoselective synthesis of cis-and trans-6, 8-dimethoxy-1, 3-dimethyl-1, 2, 3, 4-tetrahydroisoquinoline

…, PK Mohanty, DM Burns, YW Andemichael

Index: Davis; Mohanty; Burns; Andemichael Organic letters, 2000 , vol. 2, # 24 p. 3901 - 3903

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Citation Number: 60

Abstract

The highly diastereoselective addition of lateral lithiated o-tolunitriles to sulfinimines followed by treatment of the resulting sulfinamide with MeLi, hydrolysis, and reduction represents a concise new methodology for the asymmetric synthesis of 1, 3-disubstituted tetrahydroisoquinolines.