Antioxidative phenolics from the fresh leaves of Ternstroemia japonica.

Youngmi Jo, Minkyung Kim, Myung Hee Shin, Hae Young Chung, Jee H Jung, Kwang Sik Im

Index: J. Nat. Prod. 69 , 1399-403, (2006)

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Abstract

Six new phenylethanoid glucosides, ternstrosides A-F (1-6), a new kaempferol derivative (7), and eight known compounds were isolated from the fresh leaves of Ternstroemia japonica. The structures were elucidated by 1D and 2D NMR spectroscopic analyses. Compounds 1-7 showed potent antioxidative activity in three different tests, with IC50 values in the range 3.26-6.50 microM in the hydroxyl radical (*OH) inhibitory activity test, 33.29-82.21 microM in the total ROS (reactive oxygen species) inhibitory activity test, and 1.14-13.53 microM in the peroxynitrite (ONOO-) scavenging activity test.