Synthesis of 6??amino??1, 2, 3??triazolo [4, 5??c] pyridin??4 (5H) one (8??aza??3??deazaguanine) and 6??amino??1??(β??D??ribofuranosyl)??1, 2, 3??triazolo [4, 5??c] pyridin??4 (5H) …

RHB Meyer, GR Revankar, P Dan Cook…

Index: Meyer Jr.; Revankar; Cook; et al. Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 1 p. 159 - 169

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Citation Number: 13

Abstract

Abstract The total synthesis of 6-amino-1, 2, 3-triazolo [4, 5-c] pyridin-4 (5H) one (8-aza-3- deazaguanine, 3) and 6-amino-1-(β-D-ribofuranosyl)-1, 2, 3-triazolo [4, 5-c] pyridin-4 (5H) one (8-aza-3-deazaguano-sine, 22) has been described for the first time by a novel base- catalyzed ring closure of 4 (5)-cyanomethyl-1, 2, 3-triazole-5 (4) carboxamide (14) and methyl 5-cyanomethyl-1-(2, 3, 5-tri-O-ben-zoyl-β-D-ribofuranosyl)-1, 2, 3-triazole-4- ...