Nonenzymatic cleavages of peptide chains at the cysteine and serine residues through their conversion into dehydroalanine. I. Hydrolytic and oxidative cleavage of …
A Patchornik, M Sokolovsky
Index: Sokolovsky,M. et al. Journal of the American Chemical Society, 1964 , vol. 86, p. 1212 - 1217
Full Text: HTML
Citation Number: 89
Abstract
In connection with the specific chemical fragmentation of peptides and proteins, the conditions for the cleavage of dehydroalanine residues, which can be formed from cysteine and serine residues, was investigated. Dehydroalanine residues are cleaved hydrolytically at the SC, bond with nearly quantitative yield by heating the compound to 100'at pH 2 for 1 hr. The cleavage can be facilitated by oxidative activation of the molecule. Oxidation by ...
Related Articles:
Synthesis of. beta.-lactam antibiotics by the sulfeno-cycloamination
[Ihara; Haga; Yonekura; et al. Journal of the American Chemical Society, 1983 , vol. 105, # 25 p. 7345 - 7352]
Synthesis of dehydroalanine peptides from. beta.-chloroalanine peptide derivatives
[Srinivasan,A. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 2253 - 2256]
Exploration of Routes Leading to Derivatives of α??Hydroxyalanine and its Precursors
[Liwschitz,Y. et al. Israel Journal of Chemistry, 1971 , vol. 9, p. 89 - 103]
A Convenient, Large-Scale Preparation of 2-Acetamidoacrylic Acid and its Methyl Ester
[Kolar,A.J.; Olsen,R.K. Synthesis, 1977 , p. 457 - 459]
A Convenient, Large-Scale Preparation of 2-Acetamidoacrylic Acid and its Methyl Ester
[Kolar,A.J.; Olsen,R.K. Synthesis, 1977 , p. 457 - 459]