Synthetic Communications®

Novel synthesis of 4-or 6-substituted indirubin derivatives

A Zhang, M Yu, T Lan, Z Liu, Z Mao

Index: Zhang, Aiying; Yu, Mingfeng; Lan, Tian; Liu, Zenglu; Mao, Zhenmin Synthetic Communications, 2010 , vol. 40, # 21 p. 3125 - 3134

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Citation Number: 7

Abstract

A simple and convenient route for synthesis of a series of 4-or 6-substituted indirubin derivatives by oxidation and subsequent condensation of indoxyl and isatin is described. Acidic reaction conditions are crucial to the condensation of 4-substituted derivatives, whereas for the condensation of 6-substituted derivatives, both acidic and basic conditions work well.