Potential antileukemic and immunosuppressive drugs. Preparation and in vitro pharmacological activity of some 2, 1, 3-benzoxadiazoles (benzofurazans) and their N- …
PB Ghosh, MW Whitehouse
Index: Ghosh,P.B.; Whitehouse,M.W. Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 305 - 311
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Citation Number: 129
Abstract
Eight methods for synthesizing various benzo-2, 1, 3-oxadiazoles (benxofuraxans) and their S-oxides (benzofuroxans) are described. The activity of benzofurazans and benzofuroxans as in vitro inhibitors of RNA synthesis in sheep lymphocytes is given. Optimal drug aetivity in vitro was exhibited by 4-nitrobenzofuraxan and 4-nitrobenzofuroxan and their 7-thio or 7- phenoxy derivatives. These compounds readily formed Meisenheimer complexes with ...
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