Bioorganic & Medicinal Chemistry Letters 2000-09-04

Design and synthesis of triglyceride analogue biotinylated suicide inhibitors for directed molecular evolution of lipolytic enzymes.

H J Deussen, S Danielsen, J Breinholt, T V Borchert

Index: Bioorg. Med. Chem. Lett. 10(17) , 2027-31, (2000)

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Abstract

The design, synthesis, and inhibition properties of two new triglyceride analogue biotinylated suicide inhibitors (2) and (3) for directed molecular evolution of lipolytic enzymes by phage-display is described.