Tetrahedron

New and efficient synthesis of bi-and trisubstituted indazoles

…, S El Kazzouli, JM Léger, C Jarry, EM Rakib, M Khouili…

Index: Bouissane, Latifa; El Kazzouli, Said; Leger, Jean-Michel; Jarry, Christian; Rakib, El Mostapha; Khouili, Mostafa; Guillaumet, Gerald Tetrahedron, 2005 , vol. 61, # 34 p. 8218 - 8225

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Citation Number: 44

Abstract

In this paper, the synthesis of bi-and trisubstituted indazoles was described. 4-Alkoxy-7- aminoprotected-indazole or 7-aminoprotected-indazole derivatives were prepared selectively using SnCl2 in alcohol or SnCl2 in ethyl acetate, respectively. The effects of the halogen atom in position 3 and of the N-alkylation in N-1 position of 7-nitroindazoles were investigated.