Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and …
M Nazaré, DW Will, H Matter, H Schreuder…
Index: Journal of Medicinal Chemistry, , vol. 48, # 14 p. 4511 - 4525
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Citation Number: 68
Abstract
... Journal of Medicinal Chemistry. ... 2. Chemistry. We first set out to systematically probe the influence on fXa activity of a diverse set of simple substituents on the indole nucleus. The biarylic P1 ligand and the isopropylpiperidine ...
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