Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp.
K Komiyama, S Funayama, Y Anraku, A Mita, Y Takahashi, S Omura, H Shimasaki
Index: J. Antibiot. 42(9) , 1344-9, (1989)
Full Text: HTML
Abstract
Three antioxidant isoflavonoids characterized as 4',7,8-trihydroxyisoflavone (1), 3',4',7-trihydroxyisoflavone (2) and 8-chloro-3',4',5,7-tetrahydroxyisoflavone (3) were isolated from the cultured broth of Streptomyces sp. OH-1049. Among them, 3 is a novel isoflavonoid possessing a chlorine atom in the molecule. In in vitro studies, these antibiotics were found to possess antioxidant activity whereas showed almost no cytocidal activities against HeLa S3 cells.
Related Compounds
Related Articles:
Synthesis and biological studies of 4', 7, 8-trihydroxy-isoflavone metal complexes.
2011-12-01
[J. Inorg. Biochem. 105(12) , 1623-9, (2011)]
2013-07-06
[J. Antibiot. 42(9) , 1350-5, (1989)]