Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone

SP Tanis, TT Parker, JR Colca, RM Fisher…

Index: Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5053 - 5063

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Citation Number: 53

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. We elected to pursue the synthesis of metabolites 6−8 from a common pyridine precursor, methyl 6-methylnicotinate, to maximize the utility of common precursors. In order ...

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Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone

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Studies on Antidiabetic Agents. XII. Synthesis and Activity of the Metabolites of (.+-.)-5-(p-(2-(5-Ethyl-2-pyridyl) ethoxy) benzyl)-2, 4-thiazolidinedione (Pioglitazone).

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