Tetrahedron

Palladium Catalysed Tandem Cyclisation–Anion Capture. Part 6: Synthesis of Sugar, Nucleoside, Purine, Benzodiazepinone and β-lactam Analogues via Capture of …

A Casaschi, R Grigg, JM Sansano

Index: Casaschi, Adele; Grigg, Ronald; Sansano, Jose M. Tetrahedron, 2000 , vol. 56, # 38 p. 7553 - 7560

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Citation Number: 23

Abstract

The regioselective palladium catalysed hydrostannylation of alkynes bearing a β- heteroatom affords mainly α-vinyltin (IV) compounds that are used as terminating species in palladium catalysed cyclisation–anion capture processes. The pharmacophore attached to the alkyne moiety permits the synthesis of sugars, nucleosides, purines, benzodiazepinones and β-lactams analogues in good yields.