Intramolecular rhodium-catalyzed activation of α-amino C–H bonds: decisive influence of conformational factors in the synthesis of bicyclic aminals from N- …

…, P Compain, S Peyrat, J Kalinowska-Tluscik

Index: Morin, Marie S.T.; Toumieux, Sylvestre; Compain, Philippe; Peyrat, Sandrine; Kalinowska-Tluscik, Justyna Tetrahedron Letters, 2007 , vol. 48, # 48 p. 8531 - 8535

Full Text: HTML

Citation Number: 13

Abstract

The activation of α-amino C–H bonds in azacycloalkanes by way of intramolecular rhodium- catalyzed amination is reported. In this study, the 'activating'sulfamoyloxy group is attached to the endocyclic nitrogen atom with an appropriate linker. The influence of various structural parameters was studied. Results obtained demonstrate the remarkable conformational control that is possible with such azacycloalkane systems. This work leads to the first ...