Design, synthesis and anticancer activity of 4-morpholinothieno [3, 2-d] pyrimidine derivatives bearing arylmethylene hydrazine moiety

…, Q Fu, F Guo, M Bai, J Wang, H Wang, P Gong

Index: Zhu, Wufu; Zhai, Xin; Fu, Qiangqiang; Guo, Fei; Bai, Mei; Wang, Jianqiang; Wang, Haiyan; Gong, Ping Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1037 - 1045

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Citation Number: 10

Abstract

Three series of 4-morpholinothieno [3, 2-d] pyrimidine derivatives containing arylmethylene hydrazine moiety (11a–f, 13a–k and 15a–h) were synthesized and their chemical structures as well as the relative stereochemistry were confirmed. The synthesized compounds were evaluated for their cytotoxicity against three cancer cell lines (H460, HT-29, MDA-MB-231). Most of them exhibited moderate to significant cytotoxicity and high-selectivity against one ...