Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl) acetamido] thio-4H-1, 2, 4-triazole derivatives

G Turan-Zitouni, ZA Kaplancıklı, MT Yıldız…

Index: Turan-Zitouni, Guelhan; Kaplancikli, Zafer Asim; Yildiz, Mehmet Taha; Chevallet, Pierre; Kaya, Demet European Journal of Medicinal Chemistry, 2005 , vol. 40, # 6 p. 607 - 613

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Citation Number: 217

Abstract

The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this purpose, new thiazole derivatives of triazoles were synthesized and evaluated for antifungal and antibacterial activity. The reaction of propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the ...