A facile one-pot preparation of isothiocyanates from N-formamides and sulfur powder with bis (trichloromethyl) carbonate

WG Shan, GF Bian, WK Su, XR Liang

Index: Shan; Bian; Su; Liang Organic Preparations and Procedures International, 2004 , vol. 36, # 3 p. 283 - 286

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Citation Number: 8

Abstract

Isothiocyanates are one of the most important synthetic intermediates for the preparation of both sulfur and nitrogen containing organic compounds and especially heterocycles.'The synthesis of isothiocyanates has been extensively studied over the past decades, because they play an important role as anti-proliferatives2 and in the therapy of blood cancer, as enzyme inhibitors for the HIV virus. 3 Numerous methods for the synthesis of ...