Synthesis, structure–activity relationship and in vitro biological evaluation of N-arylethyl isoquinoline derivatives as Coxsackievirus B3 inhibitors

…, HQ Wang, YX Liu, LM Gao, QN Lu, JD Jiang…

Index: Wang, Yan-Xiang; Li, Yu-Huan; Li, Ying-Hong; Gao, Rong-Mei; Wang, Hui-Qiang; Liu, Yan-Xin; Gao, Li-Mei; Lu, Qiao-Ni; Jiang, Jian-Dong; Song, Dan-Qing Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5787 - 5790

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Citation Number: 5

Abstract

Currently, there is no approved antiviral drug for the infection caused by enteroviruses. A series of novel N-arylethyl isoquinoline derivatives defined with substituents on the ring A and C were designed, synthesized and evaluated in vitro for their activities against Coxsackievirus B3 (CVB3). The primary structure–activity relationship revealed that substituents on the ring A were not beneficial for the activity. Among these analogs ...