Structure–Activity Relationships (SAR) Research of Thiourea Derivatives as Dual Inhibitors Targeting both HIV??1 Capsid and Human Cyclophilin A
…, S Tang, I Hewlett, F Yu, Y Jin, M Yang
Index: Chen, Kan; Tan, Zhiwu; He, Meizi; Li, Jiebo; Tang, Shixing; Hewlett, Indira; Yu, Fei; Jin, Yinxue; Yang, Ming Chemical Biology and Drug Design, 2010 , vol. 76, # 1 p. 25 - 33
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Citation Number: 10
Abstract
HIV-1 capsid (CA) and human cyclophilin A (CypA) play important roles in HIV-1 assembly and disassembly processes, which are critical in HIV-1 replication. Based on the discovery of thiourea derivatives targeting both of the two proteins and indicating effective inhibitory activities in our group, we designed and synthesized a new class of thiourea derivatives. Their abilities to bind to capsid and cyclophilin A were determined by ultraviolet ...
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