From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist

X Zheng, KJ Hodgetts, H Brielmann, A Hutchison…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 19 p. 5217 - 5221

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Citation Number: 29

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 5 The resulting arylcarboxamides offered several possible advantages, among them: (1) increased metabolic/chemical stability; (2) more direct access to under-explored regions of the arylurea pharmacophore via substitution on the B ...