International Journal of Molecular Sciences 2012-01-01

Improved synthesis of 5-substituted 1H-tetrazoles via the [3+2] cycloaddition of nitriles and sodium azide catalyzed by silica sulfuric acid.

Zhenting Du, Changmei Si, Youqiang Li, Yin Wang, Jing Lu

Index: Int. J. Mol. Sci. 13(4) , 4696-703, (2012)

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Abstract

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%-95% yield.