Synthesis of (+-)-hexahydropronuciferine and related compounds
JW Huffman, CE Opliger
Index: Huffman,J.W.; Opliger,C.E. Journal of Organic Chemistry, 1971 , vol. 36, # 1 p. 111 - 117
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Citation Number: 5
Abstract
In an effort to develop a new synthetic approach to the proaporphine alkaloids, a method for effecting the conversion of a suitably substituted 1-indanone to a hexahydrocyclopent [ij] isoquinoline has been developed. Bobbitt's modification of the Pomeranz-Fritsch reaction applied to 4, 5-dimethoxy-l-indanone affords the corresponding cyclopentisoquinoline (5) in acceptable yield. By the same procedure demethoxydeoxystepharine (11) was prepared ...
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