Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives as potent anticancer agents

SS Karki, K Panjamurthy, S Kumar, M Nambiar…

Index: Karki, Subhas S.; Panjamurthy, Kuppusamy; Kumar, Sujeet; Nambiar, Mridula; Ramareddy, Sureshbabu A.; Chiruvella, Kishore K.; Raghavan, Sathees C. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2109 - 2116

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Citation Number: 58

Abstract

Levamisole, the imidazo [2, 1-b] thiazole derivative has been reported as a potential antitumor agent. In the present study, we synthesized, characterized and evaluated biological activity of its novel analogues with substitution in the aralkyl group and on imidazothiadiazole molecules with same chemical backbone but different side chains namely 2-aralkyl-6-(4′-fluorophenyl)-imidazo [2, 1-b][1, 3, 4] thiadiazoles (SCR1), 2- ...