Journal of Antibiotics 1987-09-01

Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocks 3-hydroxy-3-methylglutaryl coenzyme A synthase.

S Omura, H Tomoda, H Kumagai, M D Greenspan, J B Yodkovitz, J S Chen, A W Alberts, I Martin, S Mochales, R L Monaghan

Index: J. Antibiot. 40(9) , 1356-7, (1987)

Full Text: HTML

Abstract

Related Compounds

Related Articles:

Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition.

2000-01-11

[Biochemistry 39(1) , 237-47, (2000)]

Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase.

2004-02-27

[Biochim. Biophys. Acta 1636(1) , 22-8, (2004)]

Biosynthesis of antibiotic 1233A (F-244) and preparation of [14C]1233A.

1992-04-01

[J. Antibiot. 45(4) , 563-7, (1992)]

Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by antibiotic 1233A and other beta-lactones.

1990-06-15

[Biochem. Biophys. Res. Commun. 169(2) , 610-6, (1990)]

Isopentenoid synthesis in eukaryotic cells. An initiating role for post-translational control of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1993-04-01

[Arch. Biochem. Biophys. 302(1) , 265-71, (1993)]

More Articles...