3-Cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure–Activity relationships

TGM Dhar, Z Shen, HH Gu, P Chen, D Norris…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3557 - 3560

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Citation Number: 27

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 2 and Figure 3. However, the carbamate side chain of VX-148 contributes significantly to the potency of this molecule (compare VX-148 and 2). Without the side chain to enhance binding affinity, the two chemical series, exemplified by ...