Asymmetric microbial reduction of ketones: absolute configuration of trans-4-ethyl-1-(1S-hydroxyethyl) cyclohexanol

C Pinedo-Rivilla, MC Cafêu, JA Casatejada…

Index: Pinedo-Rivilla, Cristina; Cafeu, Mariana Carrara; Casatejada, Josefina Aleu; Araujo, Angela Regina; Collado, Isidro G. Tetrahedron Asymmetry, 2009 , vol. 20, # 23 p. 2666 - 2672

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Citation Number: 6

Abstract

A set of five fungal species, Botrytis cinerea, Trichoderma viride and Eutypa lata, and the endophytic fungi Colletotrichum crassipes and Xylaria sp., was used in screening for microbial biocatalysts to detect monooxygenase and alcohol dehydrogenase activities (for the stereoselective reduction of carbonyl compounds). 4-Ethylcyclohexanone and acetophenone were biotransformed by the fungal set. The main reaction pathways ...