A catalytic method for chemoselective detritylation of 5′-tritylated nucleosides under mild and heterogeneous conditions using silica sulfuric acid as a recyclable …
A Khalafi-Nezhad, A Parhami, MNS Rad, MA Zolfigol…
Index: Khalafi-Nezhad, Ali; Parhami, Abolfath; Soltani Rad, Mohammad Navid; Zolfigol, Mohammad Ali; Zare, Abdolkarim Tetrahedron Letters, 2007 , vol. 48, # 30 p. 5219 - 5222
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Citation Number: 32
Abstract
A rapid, mild and highly efficient procedure for the chemoselective deprotection of triphenylmethyl (trityl, Tr), p-anisyldiphenylmethyl (monomethoxytrityl, MMT) and di-(p-anisyl) phenylmethyl (dimethoxytrityl, DMT) groups from nucleoside trityl ethers has been established. The deprotection was achieved at room temperature, using a catalytic amount of silica sulfuric acid (SSA) in acetonitrile. The trityl nucleosides were deprotected in 2– ...
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