Synthesis of novel 1, 3, 4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents

FA Ragab, NMA Gawad, HH Georgey…

Index: Ragab, Fatma A.; Abdel Gawad, Nagwa M.; Georgey, Hanan H.; Said, Mona F. European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 645 - 654

Full Text: HTML

Citation Number: 27

Abstract

Some novel 1, 3, 4-trisubstituted pyrazoles were synthesized and screened for their anti- inflammatory and analgesic activities as well as their ulcerogenic liability. They showed anti- inflammatory and analgesic activities with better GIT tolerance than the standard drug phenylbutazone. In addition, IC50 values for 5e and 8e were recorded. Compound 5e was found to be the most active one as anti-inflammatory and analgesic agent. On the other ...