Journal of Lipid Research 1972-11-01

Synthesis of ceramides using N-hydroxysuccinimide esters.

D E Ong, R N Brady

Index: J. Lipid Res. 13(6) , 819-22, (1972)

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Abstract

Fatty acyl esters of N-hydroxysuccinimide have been used to directly N-acylate sphingenine or sphinganine, forming the corresponding ceramides. The reaction proceeds in excellent yield (84-96%) from small amounts of starting material (10-20 mg). The product ceramides are pure after one recrystallization.