Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata.
Parinuch Chumkaew, Shigeru Kato, Kan Chantrapromma
Index: Chem. Pharm. Bull. 54(9) , 1344-6, (2006)
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Abstract
Two new rocaglamide derivatives, 1-O-formylrocagloic acid (1) and 3'-hydroxy rocagloic acid (2), together with five known compounds, rocaglaol (3), rocagloic acid (4), 3'-hydroxymethylrocaglate (5), 1-O-formylmethyl rocaglate (6), and methylrocaglate (7), were isolated from the fruits of Amoora cucullata. Their structures were elucidated by spectroscopic methods. Compounds 1-3, 6, and 7 exhibited potent cytotoxicity against KB, BC, and NCI-H187 cell lines, whereas 4 and 5 showed selective cytotoxicity against NCI-H187 cell line.
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