Organic & Biomolecular Chemistry 2010-04-21

Zn(OTf)(2)-catalyzed addition of amines to carbodiimides: efficient synthesis of guanidines and unpredicted formation of Zn-N amido species.

Dongzhen Li, Jie Guang, Wen-Xiong Zhang, Yang Wang, Zhenfeng Xi

Index: Org. Biomol. Chem. 8(8) , 1816-20, (2010)

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Abstract

Zn(OTf)(2) acts as an excellent catalyst precursor for addition of various amine N-H bonds to carbodiimides under an atmosphere of air, offering a convenient synthesis of substituted guanidines with high functional-group tolerance. A Zn-N amido species is shown to act as the active species.