Intermolecular Ritter-type C–H amination of unactivated sp3 carbons

Q Michaudel, D Thevenet, PS Baran

Index: Michaudel, Quentin; Thevenet, Damien; Baran, Phil S. Journal of the American Chemical Society, 2012 , vol. 134, # 5 p. 2547 - 2550

Full Text: HTML

Citation Number: 93

Abstract

Intermolecular Ritter-type C–H amination of unactivated sp3 carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C–H amination of a variety of hydrocarbons such as cyclohexane without the ...