Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model
MT Bilodeau, AE Balitza, JM Hoffman…
Index: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 11 p. 3178 - 3182
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Citation Number: 59
Abstract
... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Merck Research Laboratories, Merck & ... 9 Scheme 1 illustrates the chemistry for the 1,8-naphthyridine series but the same chemistry was also utilized for the synthesis of 1,5- and 1,7-naphthyridines. ...
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