Beilstein Journal of Organic Chemistry 2009-01-01

Gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (MACOS).

Gjergji Shore, Michael Tsimerman, Michael G Organ

Index: .PubMed ID

Full Text: HTML

Abstract

Methodology has been developed for laying down a thin gold-on-silver film on the inner surface of glass capillaries for the purpose of catalysing benzannulation reactions. The cycloaddition precursors are flowed through these capillaries while the metal film is being heated to high temperatures using microwave irradiation. The transformation can be optimized rapidly, tolerates a wide number of functional groups, is highly regioselective, and proceeds in good to excellent conversion.

Related Compounds

Related Articles:

N-trifluoromethylthiosaccharin: an easily accessible, shelf-stable, broadly applicable trifluoromethylthiolating reagent.

2014-08-25

[Angew. Chem. Int. Ed. Engl. 53(35) , 9316-20, (2014)]

Copper-catalyzed amine-alkyne-alkyne addition reaction: an efficient method for the synthesis of gamma,delta-alkynyl-beta-amino acid derivatives.

2009-11-02

[Chemistry 15(43) , 11668-74, (2009)]

(NHC) Copper (I)-Catalyzed [3+ 2] Cycloaddition of Azides and Mono-or Disubstituted Alkynes. Díez-González S, et al.

[Chemistry 12(29) , 7558-7564, (2006)]

More Articles...