Zhurnal mikrobiologii, epidemiologii, i immunobiologii 2006-01-01

[Immunization with cellulose-immobilized antigens. The development of A. E. Gurvitch concept].

A M Liashchuk, V G Lunin, A S Kariagina, N V Lavrova, I V Rodionova, M I Kormilitsina, I S Meshcheriakova, L V Verkhovskaia, B S Naroditskiĭ, A L Gintsburg

Index: Zh. Mikrobiol. Epidemiol. Immunobiol. (4) , 65-8, (2006)

Full Text: HTML

Abstract

A highly purified TUL4-CBD chimeric protein was obtained by one stage purification method. TUL4-CBD protein consists of TUL4 Francisella tularensis mature peptide sequence, Gly-Ser spacer and cellulose binding domain (CBD) of Anaerocellum thermophilum. The TUL4-CBD protein was shown to induce production of specific antibodies to TUL4 protein in laboratory animals.