Anthraquinone derivatives as a new family of protein photocleavers

…, M Hasegawa, M Ishii, S Matsumura, K Toshima

Index: Suzuki, Akane; Hasegawa, Masashi; Ishii, Maiko; Matsumura, Shuichi; Toshima, Kazunobu Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4624 - 4627

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Citation Number: 38

Abstract

Certain anthraquinones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton.