Thermodynamic interactions of a cis and trans benzanilide with Escherichia coli bacterial membranes.
Sarah R Dennison, Timothy J Snape, David A Phoenix
Index: Eur. Biophys. J. 41(8) , 687-93, (2012)
Full Text: HTML
Abstract
The activity of a membrane interactive cis and trans benzanilide against Escherichia coli membrane mimics was investigated using Langmuir monolayers. It was found that in the presence of E. coli lipid mix monolayers, cis-benzanilide induced maximal surface pressure changes of 1 mN m(-1), whereas a reduced interaction was observed with trans-benzanilide. Compression isotherm analysis of these monolayers showed ∆G(mix) < 0, indicating membrane stabilisation by both compounds. The binding coefficient for trans-benzanilide was circa 890 μM and for the cis-benzanilide was 820 μM, suggesting that both benzanilide compounds bound to the E. coli membranes.
Related Compounds
Related Articles:
Benzanilides with spasmolytic activity: chemistry, pharmacology, and SAR.
2008-06-01
[Bioorg. Med. Chem. 16 , 5974-81, (2008)]
2009-10-01
[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 74(2) , 484-97, (2009)]
2002-09-01
[Il Farmaco 57(9) , 777-82, (2002)]
2005-12-01
[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 62(4-5) , 991-9, (2005)]
New amido derivatives as potential BKCa potassium channel activators. XI.
2008-04-01
[Eur. J. Med. Chem. 43(4) , 792-9, (2008)]