Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B 2 receptors

H Heitsch, A Wagner, BA Schölkens, K Wirth

Index: Heitsch, Holger; Wagner, Adalbert; Schoelkens, Bernward A.; Wirth, Klaus Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 3 p. 327 - 332

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Citation Number: 22

Abstract

The synthesis and the SAR study of novel O-substituted 8-quinolines and 4-benzothiazoles as highly potent non-peptide bradykinin B2 receptor antagonists are described. Several members of this series of antagonists efficiently inhibited the BK-induced vasoconstriction on different isolated organ preparations.