Phase-transfer-catalyzed michaelis-becker synthesis of dialkyl methyl phosphonates

H Fakhraian, A Mirzaei

Index: Fakhraian, Hossein; Mirzaei, Akbar Phosphorus, Sulfur and Silicon and the Related Elements, 2006 , vol. 181, # 3 p. 511 - 518

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Citation Number: 8

Abstract

A liquid–liquid phase-transfer-catalyzed (PTC) Michaelis-Becker reaction was adopted in the preparation of dialkyl methyl phosphonate (R= Me, iPr, nBu, and iBu). This was performed by the reaction of an appropriate dialkyl hydrogen phosphonate with methyl iodide in the presence of benzyl triethyl ammonium chloride and sodium hydroxide as PTC and base, respectively. A liquid–liquid two-phase system (H2O/CH2Cl2) introduced a ...