Tetrahedron

Tunable protic ionic liquids as solvent-catalysts for improved synthesis of multiply substituted 1, 2, 4-triazoles from oxadiazoles and organoamines

X Chen, R Liu, Y Xu, G Zou

Index: Chen, Xiaofeng; Liu, Rui; Xu, Yuan; Zou, Gang Tetrahedron, 2012 , vol. 68, # 24 p. 4813 - 4819

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Citation Number: 18

Abstract

More than green alternatives to traditional volatile molecular organic solvents, protic ionic liquids as dual solvent-catalysts have been successfully used to promote reactions of organoamines with oxadiazoles to afford sterically hindered 1, 2, 4-triazoles. Among the tested protic ionic liquids, pyridinium trifluoroacetate and acetate showed the highest efficiency for the reactions of arylamines and alkylamines, respectively, indicating that ...