Lipids 1993-02-01

Reduction of fatty acid hydroperoxides by human parotid saliva.

J Terao, A Nagao, H Yuki, Y Itoh

Index: Lipids 28(2) , 121-4, (1993)

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Abstract

Arachidonic acid hydroperoxide (15-hydroperoxyeicosatetraenoic acid; 15-HPETE) was introduced into human parotid saliva and incubated at 37 degrees C. Straight phase high-performance liquid chromatography analysis of the reaction mixture showed that 15-HPETE was detoxified to its reduced form, 15-hydroxyeicosatetraenoic acid, in the presence of glutathione. Therefore, it is concluded that human parotid saliva possesses fatty acid hydroperoxide-reducing ability. However, its effectiveness was found to be lower than that of blood plasma.

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