Palladium-catalyzed substitutions of triflates derived from tyrosine-containing peptides and simpler hydroxyarenes forming 4-(diethoxyphosphinyl) phenylalanines and …

KS Petrakis, TL Nagabhushan

Index: Petrakis, Konstantinos S.; Nagabhushan, Tattanahalli L. Journal of the American Chemical Society, 1987 , vol. 109, # 9 p. 2831 - 2833

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Citation Number: 91

Abstract

" General procedure: A mixture of aryl triflate (IO mmol),(EtO), POH (12 mmol), and MeMorph (13 mmol) or, for nonpeptide triflates,(i-Pr), EtN (13 mmol), Pd (PPh3),(0.3 mmol), and CH $ N (10 mL) in a sealed tube was stirred at 70 OC under N, until TLC analysis indicated complete conversion. bYield of isolated product. All compounds were fully characterized by 400-MHz'H NMR and IR spectroscopy and MS. New compounds gave satisfactory ...