A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.

Rajbir Kaur, Sheema Khan, Renu Chib, Tandeep Kaur, Parduman Raj Sharma, Jaswant Singh, Bhahwal Ali Shah, Subhash Chandra Taneja

Index: Eur. J. Med. Chem. 46 , 1356-66, (2011)

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Abstract

Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several biological end-points of the apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).Copyright © 2011 Elsevier Masson SAS. All rights reserved.