Studies on the reaction of N??(3??carbethoxy??4, 5, 6, 7??tetrahydrobenzo [b] thien??2??yl)??N′??phenylthiourea with hydrazine hydrate (Part 1)

HAH El??Sherief, GM El??Naggar…

Index: El-Sherief, Hassan A. H.; El-Naggar, Galal M.; Hozien, Zeinab A.; El-Sawaisi, Suliman M. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 2 p. 467 - 473

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Abstract

Thienopyrimidines, have been evaluated pharmacologically as anti-malarial [1] antibacterial [1, 6], analgesic and anti-inflammatory [7, 11], diuretic activity in rats [12], antiviral [13], antifungal effect [14], herbicidal activity and antimycotoxigenic activity [15]. Besides the synthetic methods of 3-amino-3, 4-dihydro-2-arylaminothieno [2, 3-d] pyrimidin-4 (3H)-ones, a new route has appeared in the literature by refluxing of N-(3-carbethoxythien-2-yl)-N'- ...