Two-dimensional NMR spectroscopy of siomycin A. Proton--carbon-13 chemical shift correlation.
N J Clayden, F Inagaki, R J Williams, G A Morris, K Tori, K Tokura, T Miyazawa
Index: Eur. J. Biochem. 123(1) , 127-31, (1982)
Full Text: HTML
Abstract
A trial application of a recent two-dimensional nuclear magnetic resonance experiment to the polypeptide antibiotic siomycin A is described. Proton--carbon-13 chemical shift correlation measures the proton and carbon-13 chemical shift for each directly bonded CH group in a molecule, in a single experiment. The resultant map of correlated chemical shifts enables the carbon-13 spectrum to be assigned directly from the known proton shifts, and allows individual proton signals to be identified without problems of overlap. The signal-to-noise ratio available from such techniques should enable their application to aqueous protein solutions using currently available high-field spectrometers.
Related Compounds
Related Articles:
A novel mode of FoxM1 regulation: positive auto-regulatory loop.
2009-06-15
[Cell Cycle 8(12) , 1966-7, (2009)]
Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells.
2009-01-01
[PLoS ONE 4(5) , e5592, (2009)]
The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.
2013-02-01
[J. Mol. Med. 91(2) , 237-48, (2013)]
FOXM1: the Achilles' heel of cancer?
2008-02-01
[Nat. Rev. Cancer 8(3) , c1; author reply c2, (2008)]
Future roles for FoxM1 inhibitors in cancer treatments.
2007-02-01
[Future Oncol. 3(1) , 1-3, (2007)]