Bioorganic & Medicinal Chemistry Letters 2007-09-01

Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.

Michael A Letavic, Emily M Stocking, Ann J Barbier, Pascal Bonaventure, Jamin D Boggs, Brian Lord, Kirsten L Miller, Sandy J Wilson, Nicholas I Carruthers

Index: Bioorg. Med. Chem. Lett. 17(17) , 4799-803, (2007)

Full Text: HTML

Abstract

The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described.

Related Compounds

Related Articles:

Synthesis and biological evaluation of 2'-oxo-2,3-dihydro-3'H- spiro[chromene-4,5'-[1,3]oxazolidin]-3'yl]acetic acid derivatives as aldose reductase inhibitors.

2011-06-01

[Arch. Pharm. (Weinheim) 344(6) , 372-85, (2011)]

Synthesis of tri-substituted biaryl based trianglimines: formation of C3-symmetrical and non-symmetrical regioisomers.

2011-05-07

[Org. Biomol. Chem. 9(9) , 3258-71, (2011)]

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.

2002-08-19

[Bioorg. Med. Chem. Lett. 12(16) , 2121-3, (2002)]

More Articles...