Effects of cytokinins, cytokinin ribosides and their analogs on the viability of normal and neoplastic human cells.

Silvana Casati, Roberta Ottria, Erika Baldoli, Elisa Lopez, Jeanette A M Maier, Pierangela Ciuffreda

Index: Anticancer Res. 31(10) , 3401-6, (2011)

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Abstract

We examined the effects of some cytokinins and cytokinin ribosides including a series of adenosine analogs differently substituted in the N(6) position, along with some hypoxanthine derivatives on the viability of normal and neoplastic human cells. Cytokinins such as trans-zeatin, isopentenyladenine and benzyladenine do not show any effect, while cytokinin ribosides such as trans-zeatin riboside, isopentenyladenosine, and benzylaminopurine riboside impair the viability of normal and neoplastic cells, apart from colon carcinoma LoVo cells.