A general method for the synthesis of unsymmetrically substituted ureas via palladium-catalyzed amidation.

Brian J Kotecki, Dilinie P Fernando, Anthony R Haight, Kirill A Lukin

Index: Org. Lett. 11 , 947, (2009)

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Abstract

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed utilizing palladium-catalyzed amidation. Both aryl bromides and chlorides, as well as heteroaryl chlorides, have been coupled to aryl, benzyl, and aliphatic ureas by using a novel nonproprietary bipyrazole ligand (bippyphos).